A convenient method for screening human PAD2 inhibitors
Features
  • Screen for inhibitors of PAD2
  • Assay 45 samples in duplicate
  • Plate-based fluorometric measurement (ex 355-365 nm, em 445-455 nm)
  • Low background, high sensitivity
  • Orthogonal assay to Cayman’s PAD2 Inhibitor Screening Assay Kit (Ammonia) (Item No. 701400)
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PAD2 Inhibitor Screening Assay Kit (AMC)

Item No. 701390

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PADI2
  • PAD-H19
  • Peptidylarginine Deiminase 2
  • Protein Arginine Deiminase 2
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    96 wells

    $543

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    • Bioanalysis and compound screening using Cayman or qualified commercial assay kits
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    Product Description

    Protein arginine deiminase 2 (PAD2) is a guanidino-modifying enzyme that catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. This enzyme has been implicated in several diseases, including rheumatoid arthritis (RA), retinal degeneration, and certain cancers. PAD2 has been shown to modify vimentin, fibrinogen, and β/γ-actin. Extracellular levels of PAD2 are increased in the lungs of smokers, providing a link between smoking as a risk factor for RA and anti-citrullinated protein antibodies among RA patients. Cayman's PAD2 Inhibitor Screening Assay Kit (AMC) provides a convenient method for screening human PAD2 inhibitors.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.