A convenient fluorometric method for screening potential inhibitors of SARS-CoV-2 main protease inhibitors
Features
  • Screen for inhibitors of SARS-CoV-2 Main Protease
  • Includes recombinant SARS-CoV-2 Main Protease and positive control inhibitor GC376
  • Assay 29 samples in triplicate
  • Plate-based fluorometric measurement (Ex./Em. = 340/490 nm, respectively)
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SARS-CoV-2 Main Protease Inhibitor Screening Assay Kit

Item No. 701960

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Severe Actue Respiratory Syndrome Coronavirus 2 Main Protease Inhibitor
Emission
490 nm
Excitation
340 nm
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    96 wells

    $632

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    Product Description

    Cayman’s SARS-CoV-2 Main Protease Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of SARS-CoV-2 Mpro, one of the proteases required for processing viral polyproteins into non-structural proteins. The assay uses a SARS-CoV-2 Mpro-specific fluorogenic substrate containing a cleavage site found between nsp4 and nsp5. SARS-CoV-2 Mpro cleaves this substrate separating an EDANS fluorophore from a Dabcyl quencher generating free EDANS, which can be easily quantified using a fluorescence plate reader at excitation and emission wavelengths of 340 and 490 nm, respectively. The SARS-CoV-2 Mpro inhibitor GC376 is included as a positive control.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.