Features
- Screen for novel substrates of the metabolic enzyme 15-PGDH
- Run 45 samples in duplicate
- Plate-based fluorescent readout
- Rapid assay: Get results in less than 1 hour
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- 15-PGDH
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Product Description
Cayman’s 15-hydroxy Prostaglandin Dehydrogenase (15-PGDH) Substrate Screening Assay Kit provides a robust and easy-to-use platform for identifying novel substrates of the metabolic enzyme 15-PGDH. Measurement of 15-PGDH activity is carried out by monitoring the rate of NAD+ reduction to NADH. The reduction of NAD+ to NADH is accompanied by an increase in fluorescence at 445 nm following excitation at 340 nm. Prostaglandin E2 (PGE2) is included as a positive control while 15-keto PGE2, an inactive metabolite of PGE2 formed by 15-PGDH, is included as a negative (background) control. This assay is also able to detect “slow” substrates, which are utilized by 15-PGDH less efficiently than PGE2.
WARNING This product is not for human or veterinary use.
Contact Info
Cayman Chemical1180 East Ellsworth RoadAnn Arbor, Michigan 48108 USAToll Free: (800) 364-9897(USA and Canada only)Fax: (734) 971-3640
