A COX inhibitor and NSAID
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Labeled Version(s)
33275Lornoxicam-d4
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Lornoxicam

Item No. 70220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide
CAS Number
70374-39-9
Synonyms
  • Chlortenoxicam
  • Ro 13-9297
Molecular Formula
C13H10ClN3O4S2
Formula Weight
371.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: <1 mg/mlDMSO: 2 mg/mlEthanol: <1 mg/mlWater: <1 mg/ml
λmax
270, 381 nm
SMILES
ClC(S1)=CC2=C1C(O)=C(C(N([H])C3=CC=CC=N3)=O)N(C)S2(=O)=O
InChi Code
InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
InChi Key
WLHQHAUOOXYABV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.1 It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; Item No. 15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg.2 Formulations containing lornoxicam have been used in the management of postoperative pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J., Fellier, H., Christoph, T., et al. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm. Res. 48(7), 369-379 (1999).

    2. Buritova, J., and Besson, J.M. Potent anti-inflammatory/analgesic effects of lornoxicam in comparison to other nsaids: A c-Fos study in the rat. Inflammopharmacology 5(4), 331-341 (1997).