A soluble guanylate cyclase inhibitor
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LY83583

Item No. 70230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(phenylamino)-5,8-quinolinedione
CAS Number
91300-60-6
Molecular Formula
C15H10N2O2
Formula Weight
250.3
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
25 mg/ml DMSO:PBS pH 7.2: can dilute to 1:175 (>140 µg/macidic PBS: <100 µg/mlbasic PBS: <100 µg/mlDMF: >25 mg/mlDMSO: >25 mg/mlEthanol: >3.8 mg/mlPBS pH 7.2: <100 µg/ml
SMILES
O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12
InChi Code
InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
InChi Key
GXIJYWUWLNHKNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $20

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    5 mg

    $72

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    10 mg

    $106

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    50 mg

    $349

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    Product Description

    LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 µM.1 LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 µM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 µM.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mülsch, A., Lückhoff, A., Pohl, U., et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch. Pharmacol. 340, 119-125 (1989).

    2. Fleisch, J.H., Haisch, K.D., Spaethe, S.M., et al. Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release. J. Pharmacol. Exp. Ther. 229, 681-689 (1984).

    3. Lüönd, R.M., McKie, J.H., and Douglas, K.T. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Biochem. Pharmacol. 45, 2547-2549 (1993).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).