A soluble guanylate cyclase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LY83583

Item No. 70230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(phenylamino)-5,8-quinolinedione
CAS Number
91300-60-6
Molecular Formula
C15H10N2O2
Formula Weight
250.3
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
25 mg/ml DMSO:PBS pH 7.2: can dilute to 1:175 (>140 µg/macidic PBS: <100 µg/mlbasic PBS: <100 µg/mlDMF: >25 mg/mlDMSO: >25 mg/mlEthanol: >3.8 mg/mlPBS pH 7.2: <100 µg/ml
SMILES
O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12
InChi Code
InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
InChi Key
GXIJYWUWLNHKNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $20

    Add

    5 mg

    $72

    Add

    10 mg

    $106

    Add

    50 mg

    $349

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 µM.1 LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 µM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 µM.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mülsch, A., Lückhoff, A., Pohl, U., et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch. Pharmacol. 340, 119-125 (1989).

    2. Fleisch, J.H., Haisch, K.D., Spaethe, S.M., et al. Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release. J. Pharmacol. Exp. Ther. 229, 681-689 (1984).

    3. Lüönd, R.M., McKie, J.H., and Douglas, K.T. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Biochem. Pharmacol. 45, 2547-2549 (1993).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).