(±)-Flurbiprofen

(±)-Flurbiprofen is a non-selective COX inhibitor (IC₅₀s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).¹ In vivo, (±)-flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.² (±)-Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.³ Formulations containing (±)-flurbiprofen have been used to manage pain and inflammation associated with arthritis.

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1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

2. Glenn, E.M., Rohloff, N., Bowman, B.J., et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3(4), 210-216 (1973).

3. Bennett, A., Houghton, J., Leaper, D.J., et al. Tumour growth and response to treatment: Beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings]. Br. J. Pharmacol. 63(2), 356P-357P (1978).