A peroxynitrite scavenger
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Ebselen

Item No. 70530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-phenyl-1,2-benzisoselenazol-3(2H)-one
CAS Number
60940-34-3
Molecular Formula
C13H9NOSe
Formula Weight
274.2
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/ml
λmax
230, 263, 330 nm
SMILES
O=c1c2ccccc2[se]n1c1ccccc1
InChi Code
InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChi Key
DYEFUKCXAQOFHX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    25 mg

    $79

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    50 mg

    $143

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    100 mg

    $256

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    Product Description

    Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M−1s−1.1 The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at micromolar concentrations.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett. 398(2-3), 179-182 (1996).

    2. Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem. Pharmacol. 36(19), 3095-3102 (1987).

    3. Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem. Pharmacol. 33(20), 3247-3250 (1984).