A potent inhibitor of thromboxane synthase
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Furegrelate (sodium salt)

Item No. 70540

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3-pyridinylmethyl)-2-benzofurancarboxylic acid, sodium salt
CAS Number
85666-17-7
Synonyms
  • U-63557A
Molecular Formula
C15H10NO3 • Na
Formula Weight
275.2
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 21 mg/mlEthanol: 14.5 mg/mlPBS pH 7.2: 16.5 mg/ml
SMILES
O=C(C1=CC2=C(O1)C=CC(CC3=CN=CC=C3)=C2)[O-].[Na+]
InChi Code
InChI=1S/C15H11NO3.Na/c17-15(18)14-8-12-7-10(3-4-13(12)19-14)6-11-2-1-5-16-9-11;/h1-5,7-9H,6H2,(H,17,18);/q;+1/p-1
InChi Key
XBTIPIZROJAKOJ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $118

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    50 mg

    $481

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    Product Description

    Furegrelate is a potent inhibitor of thromboxane synthase with little effect on other enzymes essential for arachidonate metabolism. The IC50 value is 15 nM for human platelet microsomal thromboxane synthase.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, R.J., Nidy, E.G., Aiken, J.W., et al. Thromboxane A2 synthase inhibitors. 5-(3-pyridylmethyl)benzofuran-2-carboxylic acids. J. Med. Chem. 29, 1461-1468 (1986).

    2. Gorman, R.R., Johnson, R.A., Spilman, C.H., et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. Prostaglandins 26, 325-342 (1983).

    Product Citations

    Enami, Y., Bandi, S., Kapoor, S., et al. Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition. Gastroenterology 136(7), 2356-2364 (2009).