A competitive inhibitor of COX-1 and -2
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Meclofenamate (sodium salt)

Item No. 70550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, monosodium salt
CAS Number
6385-02-0
Synonyms
  • Meclofenamic Acid
Molecular Formula
C14H10Cl2NO2 • Na
Formula Weight
318.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >39 mg/mlDMSO: >75 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): <50 µg/mlPBS (pH 9.0): >50 mg/ml
SMILES
ClC1=C(N([H])C2=C(C([O-])=O)C=CC=C2)C(Cl)=C(C)C=C1.[Na+]
InChi Code
InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;/h2-7,17H,1H3,(H,18,19);/q;+1/p-1
InChi Key
OGPIIGMUPMPMNT-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271(2), 927-934 (1994).