A selective COX2 inhibitor
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NS 398

Item No. 70590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
CAS Number
123653-11-2
Molecular Formula
C13H18N2O5S
Formula Weight
314.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Corn oil: 1 mg/ml (forms a colloidal susDMF: 30 mg/mlDMSO: 25 mg/mlDMSO-PBS (1:3): 400 µg/mlEthanol: 500 µg/mlEthanol-PBS (1:1): 4 mg/ml
λmax
214, 238, 296, 337 nm
SMILES
O=S(NC1=C(OC2CCCCC2)C=C([N+]([O-])=O)C=C1)(C)=O
InChi Code
InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChi Key
KTDZCOWXCWUPEO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $83

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    25 mg

    $152

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    50 mg

    $220

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    Product Description

    NS 398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 µM, respectively.1 The IC50 values for ovine COX-1 and -2 are 220 and 0.15 µM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    2. Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324(1), 26-34 (1995).

    Product Citations

    Gokulan, R.C., Paulrasu, K., Azfar, J., et al. Protein adduction causes non-mutational inhibition of p53 tumor suppressor. Cell Rep. 42(1), 112024 (2023).

    Inazumi, T., Yamada, K., Shirata, N., et al. Prostaglandin E2-EP4 axis promotes lipolysis and fibrosis in adipose tissue leading to ectopic fat deposition and insulin resistance. Cell Rep. 33(2), 108265 (2020).

    Nandi, P., Girish, G.V., Majumder, M., et al. PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells. BMC Cancer 17(11), (2017).

    An, Y., Belevych, N., Wang, Y., et al. Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. J. Neurosci. Res. 92(4), 486-495 (2014).

    Roh, Y.J., Park, Y.G., Kang, S., et al. Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells. Graefes Arch. Clin. Exp. Ophthalmol. 250(12), 1765-1775 (2012).

    Larrieu-Lahargue, F., Welm, A.L., Bouchecareilh, M., et al. Blocking fibroblast growth factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. PLoS One 7(6), e39540 (2012).

    Dai, L., Perera, D.S., King, D.W., et al. Hemokinin-1 stimulates prostaglandin E2 production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase. J. Pharmacol. Exp. Ther. 340(1), 27-36 (2012).

    Baumgartner, L., Sosa, S., Atanasov, A.G., et al. Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. J. Nat. Prod. 74(8), 1779-1786 (2011).

    Stanikunaite, R., Khan, S.I., Trappe, J.-M., et al. Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytother. Res. 23(4), 575-578 (2009).

    Zhong, H., Willard, M., and Simons, J. NS398 reduces hypoxia-inducible factor (HIF)-1a and HIF-1 activity: Multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int. J. Cancer 112, 585-595 (2004).

    Sun, W.H., Tsuji, S., Gunawan, E.S., et al. Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. Pharmacol. Exp. Ther. 295(2), 447-452 (2000).