A natural phenolic that inhibits both 12- and 5-LO
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3,4-Dihydroxyphenyl ethanol

Item No. 70604

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-hydroxyethyl)-1,2-benzenediol
CAS Number
10597-60-1
Synonyms
  • Ba2774
  • DOPET
  • 3-Hydroxytyrosol
Molecular Formula
C8H10O3
Formula Weight
154.2
Purity
≥98%
Formulation
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Organic solvents: freely soluble (>50 mg/ml)PBS pH 7.2: >50 mg/ml
SMILES
OCCc1ccc(O)c(O)c1
InChi Code
InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
InChi Key
JUUBCHWRXWPFFH-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $61

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    50 mg

    $186

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    100 mg

    $236

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    Product Description

    3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 µM, respectively. It does not inhibit, and may actually enhance, COX activity.1 3,4-Dihydroxyphenyl ethanol also protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kohyama, N., Nagata, T., Fujimoto, S., et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci. Biotechnol. Biochem. 61(2), 347-350 (1997).

    2. Grignaffini, P., Roma, P., Galli, C., et al. Protection of low-density lipoprotein from oxidation by 3,4-dihydroxyphenylethanol. Lancet 343(8908), 1296-1297 (1994).