A selective COX-2 inhibitor
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DuP-697

Item No. 70645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene
CAS Number
88149-94-4
Molecular Formula
C17H12BrFO2S2
Formula Weight
411.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 54 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 15 mg/mlEthanol: 7 mg/ml
λmax
254, 300 nm
SMILES
Fc1ccc(cc1)c1sc(Br)cc1c1ccc(cc1)S(=O)(=O)C
InChi Code
InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3
InChi Key
AJFTZWGGHJXZOB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $121

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    10 mg

    $193

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    25 mg

    $448

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    50 mg

    $833

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    Product Description

    DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.1 When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1.2 The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively.3 The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 µM.3 DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kargman, S., Wong, E., Greig, G.M., et al. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochem. Pharmacol. 52, 1113-1125 (1996).

    2. Seibert, K., Masferrer, J., Needleman, P., et al. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. Br. J. Pharmacol. 117, 1016-1020 (1996).

    3. Johnson, J.L. . (2000).

    4. Rosenstock, M., Danon, A., and Rimon, G. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochim. Biophys. Acta 1440, 127-137 (1999).

    Product Citations

    Tamayose, C.I., Romoff, P., Toyama, D.O., et al. Non-clinical studies for evaluation of 8-C-rhamnosyl apigenin purified from Peperomia obtusifolia against acute edema. Int. J. Mol. Sci. 18(9), E1972 (2017).

    Lee, S.H., Son, M.J., Ju, H.K., et al. Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells. Biol. Pharm. Bull. 27(6), 786-788 (2004).