A selective COX-2 inhibitor
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Pro-drug Form(s)
29623Talniflumate
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Niflumic Acid

Item No. 70650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
CAS Number
4394-00-7
Synonyms
  • Donalgin
  • Nifluril
  • UP83
Molecular Formula
C13H9F3N2O2
Formula Weight
282.2
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 65 mg/mlDMSO: 44 mg/mlEthanol: 39 mg/mlPBS (pH 7.2): 600 µg/ml
λmax
289, 340 nm
SMILES
OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F
InChi Code
InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
InChi Key
JZFPYUNJRRFVQU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    50 g

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    Product Description

    Niflumic acid is a selective inhibitor of COX-2. The IC50 values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.1 The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    2. Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324(1), 26-34 (1995).