A selective COX-2 inhibitor
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SC-58125

Item No. 70655

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
CAS Number
162054-19-5
Molecular Formula
C17H12F4N2O2S
Formula Weight
384.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (1:3): 250 µg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
255 nm
SMILES
FC(C=C1)=CC=C1C2=CC(C(F)(F)F)=NN2C3=CC=C(S(=O)(C)=O)C=C3
InChi Code
InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChi Key
JHBIMJKLBUMNAU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $19

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    5 mg

    $74

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    10 mg

    $130

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    25 mg

    $283

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    Product Description

    SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.1 When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.2 In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM.3 It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seibert, K., Zhang, Y., Leahy, K., et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 91(25), 12013-12017 (1994).

    2. Anderson, G.D., Hauser, S.D., McGarity, K.L., et al. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J. Clin. Invest. 97, 2672-2679 (1996).

    3. Miralpeix, M., Camacho, M., López-Belmonte, J., et al. Selective induction of cyclo-oxygenase-2 activity in the permanent human endothelial cell line HUV-EC-C: Biochemical and pharmacological characterization. Br. J. Pharmacol. 121, 171-180 (1997).

    4. Sheng, H., Shao, J., Kirkland, S.C., et al. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Invest. 99, 2254-2259 (1997).

    Product Citations

    Eligini, S., Violi, F., Banfi, C., et al. Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism. Cardiovasc. Res. 69(1), 218-226 (2006).