A phospholipase inhibitor
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Methyl γ-Linolenyl Fluorophosphonate

Item No. 70664

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6Z,9Z,12Z-octadecatrienyl-phosphonofluoridic acid, methyl ester
CAS Number
1370451-91-4
Synonyms
  • MγLnFP
Molecular Formula
C19H34FO2P
Formula Weight
344.4
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/mlEthanol: 3.5 mg/mlPBS (7.2): <0.5 mg/ml (colloidal suspensi
SMILES
CCCCC/C=C\C/C=C\C/C=C\CCCCCP(=O)(F)OC
InChi Code
InChI=1S/C19H34FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(20,21)22-2/h7-8,10-11,13-14H,3-6,9,12,15-19H2,1-2H3/b8-7-,11-10-,14-13-
InChi Key
PYIHGLSRUVHCML-JPFHKJGASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $95

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    5 mg

    $417

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    10 mg

    $739

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    Product Description

    MγLnFP is an analog of methyl arachidonyl fluozophosphonate (MAFP; Item No. 70660), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand.1,2,3 The pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Z., Liu, S., Street, I., et al. Methyl arachidonyl fluorophosphonate, a potent irreversible cPLA2 inhibitor, blocks the mobilization of arachidonic acid in human platelets and neutrophils. Mediators Inflamm. 3, 307-308 (1994).

    2. Deutsch, D.G., Omeir, R., Arreaza, G., et al. Methyl arachidonyl fluorophosphonate: A potent irreversible inhibitor of anandamide amidase. Biochem. Pharmacol. 53, 255-260 (1997).

    3. Lio, Y.C., Reynolds, L.J., Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim. Biophys. Acta 1302(1), 55-60 (1996).