A selective, irreversible inhibitor of COX-1
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Valeroyl Salicylate

Item No. 70670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1-oxopentyl)oxy]-benzoic acid
CAS Number
64206-54-8
Synonyms
  • 2-Valeryloxybenzoic Acid
Molecular Formula
C12H14O4
Formula Weight
222.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 40 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 5 mg/ml
SMILES
CCCCC(=O)Oc1ccccc1C(=O)O
InChi Code
InChI=1S/C12H14O4/c1-2-3-8-11(13)16-10-7-5-4-6-9(10)12(14)15/h4-7H,2-3,8H2,1H3,(H,14,15)
InChi Key
WJHZBTMHUNVIKC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $58

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    100 mg

    $109

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    500 mg

    $515

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    1 g

    $858

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    Product Description

    Valeroyl salicylate is a selective, irreversible inhibitor of cyclooxygenase-1 (COX-1). The IC50 values for ovine COX-1 and -2 are 0.8 and 15 mM, respectively.1 The half-lives for inactivation of human recombinant and ovine COX-1 in the presence of 500 µM valeroyl salicylate are 12 and 45 minutes, respectively.2,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324(1), 26-34 (1995).

    2. Bhattacharyya, D.K., Lecomte, M., Dunn, J., et al. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch. Biochem. Biophys. 317(1), 19-24 (1995).