Celastrol (CAS 34157-83-0) | Cayman Chemical
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Celastrol

Item № 70950
CAS № 34157-83-0
Purity ≥98%
product image
                (CAS 34157-83-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $61.00 0.00
     10 mg $116.00 0.00
     50 mg $488.00 0.00
     100 mg $854.00 0.00

Pricing updated 2019-02-20. Prices are subject to change without notice.

Description

A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health.1,2,3 Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from Chinese thunder god vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.4

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Technical Information
Formal Name
3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
CAS Number
34157-83-0
Molecular Formula
C29H38O4
Formula Weight
450.6
Purity
≥98%
Formulation
A crystalline solid
λmax
253, 424 nm
SMILES
O=C1C=C2C(=CC=C3[C@@]2(C)CCC2(C)[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@]32C)C(=O)O)C(=C1O)C
InChI Code
InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26?,27+,28-,29+/m1/s1
InChI Key
KQJSQWZMSAGSHN-KUDKLYNCSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids Life Sciences 64, 2511-2521 (1999).

2. Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases Prostaglandins & Other Lipid Mediators 56, 131-143 (1998).

3. Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine Clinical Chemistry 41, 1789-1789 (1995).

4. Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria Biochemical and Biophysical Research Communications 172(2), 890-897 (1990).

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