An HIF-PH inhibitor
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DMOG

Item No. 71210

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(methoxyoxoacetyl)-glycine, methyl ester
CAS Number
89464-63-1
Synonyms
  • Dimethyloxallyl Glycine
Molecular Formula
C6H9NO5
Formula Weight
175.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
COC(=O)CNC(=O)C(=O)OC
InChi Code
InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChi Key
BNJOZDZCRHCODO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $28

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    50 mg

    $90

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    100 mg

    $165

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    500 mg

    $482

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    Product Description

    DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.1 DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jaakkola, P., Mole, D.R., Tian, Y.M., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292(5516), 468-472 (2001).

    2. Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294(5545), 1337-1340 (2001).

    3. Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292(5516), 464-468 (2001).

    Product Citations

    Yuan, Q., Bleiziffer, O., Boos, A.M., et al. PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat. BMC Biotechnol. 14, 112 (2014).