An inhibitor of prolyl 4-hydroxylase
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1,4-DPCA

Item No. 71220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4α-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid
CAS Number
331830-20-7
Synonyms
  • 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid
Molecular Formula
C13H8N2O3
Formula Weight
240.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
216, 242, 261, 280, 317, 332
SMILES
O=C1C2=C(C3=NC=CC=C3C=C2)N([H])C=C1C(O)=O
InChi Code
InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18)
InChi Key
XZZHOJONZJQARN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $96

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    25 mg

    $209

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    50 mg

    $367

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    Product Description

    1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase in embryonic chick tendon cells and of collagen hydroxylation in human foreskin fibroblasts with an IC50 value of 3.6 and 2.4 µM, respectively.1 β-oxocarboxylic acids such as 1,4-DPCA have also been found to inhibit the asparaginyl-hydroxylase, factor inhibiting HIF (FIH), with an IC50 value of 60 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Franklin, T.J., Morris, W.P., Edwards, P.N., et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. Biochem. J. 353, 333-338 (2001).

    2. Banerji, B., Conejo-Garcia, A., McNeill, L.A., et al. The inhibiton of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids. Chem. Commun. (Camb.) (43), 5438-5440 (2005).