An exceptionally potent FAAH inhibitor
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CAY10401

Item No. 71652

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
CAS Number
288862-89-5
Molecular Formula
C24H34N2O2
Formula Weight
382.5
Purity
≥98%
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:1): .15 mg/mlEthanol: 20 mg/ml
λmax
234, 297 nm
SMILES
CCCCCCCCCCCCCCCCCC(=O)c1nc2ncccc2o1
InChi Code
InChI=1S/C24H34N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21(27)24-26-23-22(28-24)19-17-20-25-23/h17,19-20H,2-8,11-16,18H2,1H3
InChi Key
DBMKKVSGBYKSFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $54

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    500 µg

    $244

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    1 mg

    $432

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    5 mg

    $1,887

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    Product Description

    Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM.1 CAY10401 is approximately 580 fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boger, D.L., Sato, H., Lerner, A.E., et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide. Proc. Natl. Acad. Sci. USA 97(10), 5044-5049 (2000).

    Product Citations

    Endsley, M.P., Thill, R., Choudhry, I., et al. Expression and function of fatty acid amide hydrolase in protstate cancer. Int. J. Cancer 123(6), 1318-1326 (2008).