Selective agonist for LXRα and LXRβ
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T0901317

Item No. 71810

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
CAS Number
293754-55-9
Molecular Formula
C17H12F9NO3S
Formula Weight
481.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 100 mg/mlDMSO: 100 mg/mlDMSO:PBS (1:1): 500 µg/mlEthanol: 50 mg/ml
λmax
227, 265, 272 nm
SMILES
O=S(=O)(c1ccccc1)N(CC(F)(F)F)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
InChi Code
InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChi Key
SGIWFELWJPNFDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $50

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    50 mg

    $137

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    100 mg

    $224

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    Product Description

    T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Repa, J.J., Turley, S.D., Lobaccaro, J.M.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289(5484), 1524-1529 (2000).

    Product Citations

    Cashikar, A.G., Toral-Rios, D., Timm, D., et al. Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol. J. Lipid Res. 64(4), 100350 (2023).

    Cherian, M.T., Lin, W., Wu, J., et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol. Pharmacol. 87(5), 878-889 (2015).

    Wang, X., Li, J., Xu, C., et al. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug. Chem. 25(11), 2046-2054 (2014).

    Adlakha, Y.K., Khanna, S., Singh, R., et al. Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis. Cell Death Dis. 4, e780 (2013).

    Liang, H., Zhong, Y., Zhou, S., et al. Palmitic acid-induced apoptosis in pancreatic β-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate. in vivo 25(5), 711-718 (2011).