A trifluoromethyl analog of a selective caspase inhibitor
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CAY10406

Item No. 72510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-1-benzyl-5-(1-[2-(phenoxy-p-trifluoromethyl)-pyrrolidynyl]-sulfonyl)-isatin
CAS Number
2108603-03-6
Molecular Formula
C27H23F3N2O5S
Formula Weight
544.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:2): 0.5 mg/mlDMSO: 10 mg/mlEthanol: .05 mg/ml
SMILES
O=C(C1=CC(S(N2[C@H](COC3=CC=C(C(F)(F)F)C=C3)CCC2)(=O)=O)=CC=C1N4CC5=CC=CC=C5)C4=O
InChi Code
InChI=1S/C27H23F3N2O5S/c28-27(29,30)19-8-10-21(11-9-19)37-17-20-7-4-14-32(20)38(35,36)22-12-13-24-23(15-22)25(33)26(34)31(24)16-18-5-2-1-3-6-18/h1-3,5-6,8-13,15,20H,4,7,14,16-17H2/t20-/m0/s1
InChi Key
SNBVQFYPQBMLQY-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $152

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    10 mg

    $240

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    Product Description

    CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7.1 The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are 'effector caspases' that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is currently available for caspase inhibition by CAY10406.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, D., Long, S.A., Murray, J.H., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J. Med. Chem. 44(12), 2015-2026 (2001).