A potent, selective 20-HETE synthase inhibitor
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HET0016

Item No. 75780

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-butyl-2-methylphenyl)-N'-hydroxy-methanimidamide
CAS Number
339068-25-6
Synonyms
  • N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine
Molecular Formula
C12H18N2O
Formula Weight
206.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:1): 0.5 mg/mlEthanol: 14 mg/ml
λmax
210, 257, 291 nm
SMILES
CCCCC1=CC=C(/N=C/NO)C(C)=C1
InChi Code
InChI=1S/C12H18N2O/c1-3-4-5-11-6-7-12(10(2)8-11)13-9-14-15/h6-9,15H,3-5H2,1-2H3,(H,13,14)
InChi Key
LYNOGBKNFIHKLE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $19

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    5 mg

    $74

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    10 mg

    $130

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    100 mg

    $962

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    Product Description

    HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.1,2 HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the µM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 µM, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miyata, N., Taniguchi, K., Seki, T., et al. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br. J. Pharmacol. 133, 325-329 (2001).

    2. Kehl, F., Cambj-Sapunar, L., Maier, K., et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. Am. J. Physiol. Heart Circ. Physiol. 282, H1556-H1565 (2002).