A SOD mimetic and peroxynitrite decomposition catalyst
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Mn(III)TMPyP

Item No. 75852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride
Molecular Formula
C44H36MnN8 • 5Cl
Formula Weight
909.0
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M Tris-HCl, 1 mM EDTA, pH 9.0: >100 mg/mlaqueous buffers (pH 1-9): >50 mg/mlPBS (pH 7.2): >4 mg/ml
λmax
469 nm
SMILES
C[N+]1=CC=C(C=C1)C2=C(C=C3)[N]4=C3C(C5=CC=[N+](C)C=C5)=C6[N-]7[Mn+3]84[N-]9C2=CC=C9C(C(C=C%10)=CC=[N+]%10C)=C(C=C%11)[N]8=C%11C(C%12=CC=[N+](C)C=C%12)=C7C=C6.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
InChi Code
InChI=1S/C44H36N8.5ClH.Mn/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;;;;;;/h5-28H,1-4H3;5*1H;/q+2;;;;;;+3/p-5
InChi Key
OHZZTXYKLXZFSZ-UHFFFAOYSA-I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $20

    Add

    25 mg

    $43

    Add

    50 mg

    $81

    Add

    100 mg

    $142

    Add
    Product Description

    Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.1 SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.1,2 Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem. Biol. 4(11), 845-858 (1997).

    2. Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. The Journal of Biological Chemisty 269(38), 23471-23476 (1994).