A non-selective inhibitor of all NOS isoforms
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L-NIO (hydrochloride)

Item No. 80320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-(1-iminoethyl)-L-ornithine, dihydrochloride
CAS Number
36889-13-1
Molecular Formula
C7H15N3O2 • 2HCl
Formula Weight
246.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/mlWater: 100 mg/ml
SMILES
CC(=N)NCCC[C@H](N)C(=O)O
InChi Code
InChI=1S/C7H15N3O2/c1-5(8)10-4-2-3-6(9)7(11)12/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12)
InChi Key
UYZFAUAYFLEHRC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $19

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    10 mg

    $33

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    50 mg

    $130

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    100 mg

    $228

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    Product Description

    L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 µM, respectively.1 L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Babu, B.R., and Griffith, O.W. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. The Journal of Biological Chemisty 273(15), 8882-8889 (1998).

    2. Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101(3), 746-752 (1990).