A potent, selective nNOS inhibitor
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Vinyl-L-NIO (hydrochloride)

Item No. 80330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-(1-imino-3-butenyl)-L-ornithine, monohydrochloride
CAS Number
728944-69-2
Molecular Formula
C9H17N3O2 • HCl
Formula Weight
235.7
Purity
≥95%
Formulation
A film
Solubility(Learn about Variance in Solubility)
DMF: 60 mg/mlDMSO: 50 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C=CCC(NCCC[C@H](N)C(O)=O)=N.Cl
InChi Code
InChI=1S/C9H17N3O2.ClH/c1-2-4-8(11)12-6-3-5-7(10)9(13)14;/h2,7H,1,3-6,10H2,(H2,11,12)(H,13,14);1H
InChi Key
DIWIMDZKSYTKCZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $61

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    10 mg

    $112

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    50 mg

    $462

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    100 mg

    $807

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    Product Description

    Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.1 In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min−1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Babu, B.R., and Griffith, O.W. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. The Journal of Biological Chemisty 273(15), 8882-8889 (1998).