A potent NOS inhibitor
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S-methyl-L-Thiocitrulline (hydrochloride)

Item No. 80585

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-[imino(methylthio)methyl]-L-ornithine, dihydrochloride
CAS Number
209589-59-3
Synonyms
  • SMTC
  • methyl-TC
Molecular Formula
C7H15N3O2S • 2HCl
Formula Weight
278.2
Purity
≥97%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >14 mg/mlDMSO: >20 mg/mlEthanol: >75 mg/mlPBS pH 7.2: >25 mg/ml
SMILES
CS/C(N([H])CCC[C@H](N)C(O)=O)=N/[H].Cl.Cl
InChi Code
InChI=1S/C7H15N3O2S.2ClH/c1-13-7(9)10-4-2-3-5(8)6(11)12;;/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12);2*1H
InChi Key
JNZHDSKJUXGYRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $63

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    50 mg

    $263

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    100 mg

    $451

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    Product Description

    S-methyl-L-Thiocitrulline is a potent NOS inhibitor with selectivity toward the neuronal isoform compared to eNOS and iNOS. For human enzymes, it exhibits Ki values of 1.2, 11, and 40 nM for nNOS, eNOS, and iNOS, respectively.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Narayanan, K., Spcak, L., McMillan, K., et al. S-Alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. The Journal of Biological Chemisty 270(19), 11103-11110 (1995).

    2. Furfine, E.S., Harmon, M.F., Paith, J.E., et al. Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. The Journal of Biological Chemisty 269(43), 26677-26683 (1994).