A potent and selective competitive inhibitor of nNOS
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Nω-propyl-L-Arginine

Item No. 80587

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-[imino(propylamino)methyl]-L-ornithine
CAS Number
137361-05-8
Molecular Formula
C9H20N4O2
Formula Weight
216.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: <50 µg/mlDMSO: <50 µg/mlEthanol: 10 mg/mlPBS pH 7.2: 25 mg/ml
SMILES
[H]/N=C(N([H])CCC[C@@H](C(O)=O)N)/N(CCC)[H]
InChi Code
InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13)
InChi Key
AOMXURITGZJPKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $112

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    50 mg

    $462

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    100 mg

    $807

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    Product Description

    Nω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). Nω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a Ki value of 57 nM.1 The Ki values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 µM, respectively. Nω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, H.Q., Fast, W., Marletta, M.A., et al. Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J. Med. Chem. 40(24), 3869-3870 (1997).