A potent, relatively selective inhibitor of iNOS
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AMT (hydrochloride)

Item No. 81010

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dihydro-6-methyl-4H-1,3-thiazin-2-amine, hydrochloride
CAS Number
21463-31-0
Molecular Formula
C5H10N2S • HCl
Formula Weight
166.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >8 mg/mlDMSO: >16 mg/mlEthanol: >25 mg/mlWater: >25 mg/ml
SMILES
CC1CCN=C(N)S1
InChi Code
InChI=1S/C5H10N2S.ClH/c1-4-2-3-7-5(6)8-4;/h4H,2-3H2,1H3,(H2,6,7);1H
InChi Key
HVJCRMIQAMEJNM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $120

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    50 mg

    $493

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    100 mg

    $783

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    Product Description

    AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakane, M., Klinghofer, V., Kuk, J.E., et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol. Pharmacol. 47(4), 831-834 (1995).