A selective, specific inhibitor of GTP cyclohydrolase I
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2,4-Diamino-6-hydroxypyrimidine

Item No. 81260

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-diamino-6(1H)-pyrimidinone
CAS Number
56-06-4
Synonyms
  • DAHP
Molecular Formula
C4H6N4O
Formula Weight
126.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >14.4 mg/mlDMSO: >14.6 mg/mlEthanol: <50 µg/mlPBS pH 7.2: >3.3 mg/ml
SMILES
Nc1cc(O)nc(N)n1
InChi Code
InChI=1S/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9)
InChi Key
SWELIMKTDYHAOY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $29

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    5 g

    $55

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    10 g

    $82

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    25 g

    $103

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    Product Description

    2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Werner-Felmayer, G., Werner, E.R., Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. The Journal of Biological Chemisty 268, 1842-1846 (1993).

    2. Sung, Y.J., Hotchkiss, J.H., and Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int. J. Immunopharmacol. 16(2), 101-108 (1994).

    3. Gross, S.S., and Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. The Journal of Biological Chemisty 267(36), 25722-25729 (1992).