A potent inhibitor of NOS
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S-ethyl Isothiourea (hydrobromide)

Item No. 81275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
ethyl carbamimidothioate, hydrobromide
CAS Number
1071-37-0
Synonyms
  • Ethiron bromide
  • 2-Ethyl-2-thiopseudourea hydrobromide
  • SEIT (HBr)
  • WR 539
Molecular Formula
C3H8N2S • HBr
Formula Weight
185.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
N/C(SCC)=N/[H].Br
InChi Code
InChI=1S/C3H8N2S.BrH/c1-2-6-3(4)5;/h2H2,1H3,(H3,4,5);1H
InChi Key
SWXXKWPYNMZFTE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $19

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    100 mg

    $33

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    500 mg

    $130

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    1 g

    $228

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    Product Description

    S-ethyl Isothiourea (SEIT) is a potent inhibitor of NOS in vitro but lacks good in vivo efficacy due to poor cellular penetration. The Ki values are 19, 39, and 29 nM using purified human iNOS, eNOS, and nNOS, respectively.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. The Journal of Biological Chemisty 269(43), 26669-26676 (1994).

    2. Nakane, M., Klinghofer, V., Kuk, J.E., et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol. Pharmacol. 47(4), 831-834 (1995).

    3. Southan, G.J., Szabó, C., and Thiemermann, C. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol. 114, 510-516 (1995).