A selective, competitive inhibitor of nNOS
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S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

Item No. 81280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(trifluoromethyl)phenyl]-carbamimidothioic acid, ethyl ester, monohydrochloride
CAS Number
163490-78-6
Synonyms
  • EPIT
Molecular Formula
C10H11F3N2S • HCl
Formula Weight
284.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >54 mg/mlDMSO: >33.6 mg/mlEthanol: >55 mg/mlEthanol:PBS (pH 7.2) 1:3: 1 mg/mlPBS pH 7.2: <50 µg/mlWater: 50 mg/ml
λmax
245 nm
SMILES
CCS/C(N([H])C1=CC=C(C(F)(F)F)C=C1)=N\[H].Cl
InChi Code
InChI=1S/C10H11F3N2S.ClH/c1-2-16-9(14)15-8-5-3-7(4-6-8)10(11,12)13;/h3-6H,2H2,1H3,(H2,14,15);1H
InChi Key
UVJQIYZYQQKIAC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

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    25 mg

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    100 mg

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    Product Description

    EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 µM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shearer, B.G., Lee, S., Oplinger, J.A., et al. Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J. Med. Chem. 40, 1901-1905 (1997).