A potent non-selective inhibitor of NOS
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S-methyl Isothiourea (hemisulfate)

Item No. 81300

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Methyl carbamimidothioate, hemisulfate
CAS Number
867-44-7
Synonyms
  • SMIT
Molecular Formula
2(C2H6N2S) • H2SO4
Formula Weight
278.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 14 mg/ml
SMILES
NC(SC)=N.O=S(O)(O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $29

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    Product Description

    SMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. The Journal of Biological Chemisty 269(43), 26669-26676 (1994).