An inhibitor of nNOS and iNOS
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TRIM

Item No. 81310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(trifluoromethyl)phenyl]-1H-imidazole
CAS Number
25371-96-4
Synonyms
  • 1-(α,α,α-trifluoro-o-tolyl)-Imidazole
Molecular Formula
C10H7N2F3
Formula Weight
212.2
Purity
≥98%
Formulation
A crystalline solid
λmax
263 nm
SMILES
FC(F)(F)c1ccccc1n1cncc1
InChi Code
InChI=1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H
InChi Key
WZBWBNCQUTXYEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $37

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    100 mg

    $69

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    250 mg

    $158

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    500 mg

    $280

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    Product Description

    TRIM is an inhibitor of nNOS and iNOS. It exhibits IC50 values of 28.2 µM, 27.0 µM, and 1.06 mM for the inhibition of nNOS (mouse), iNOS (rat), and eNOS (bovine), respectively.1 TRIM inhibits mouse nNOS with Ki values of 47.3 and 462 µM in the absence and presence of BH4, respectively, suggesting TRIM interferes with both arginine and tetrahydrobiopterin binding.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Handy, R.L.C., Wallace, P., Gaffen, Z.A., et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br. J. Pharmacol. 116, 2349-2350 (1995).

    2. Handy, R.L.C., and Moore, P.K. Mechanism of the inhibition of neuronal nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM). Life Sci. 60, 389-394 (1997).