A non-selective inhibitor of NOS isoforms
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7-Nitroindazole

Item No. 81340

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-nitro-1H-indazole
CAS Number
2942-42-9
Molecular Formula
C7H5N3O2
Formula Weight
163.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetone: 10 mg/mlDMF: >54 mg/mlDMSO: >100 mg/mlDMSO:10 mM Na2CO3 (10:90): 1 mg/mlEthanol: 2.68 mg/mlEthyl Acetate: 10 mg/mlPBS pH 7.2: <50 µg/ml
λmax
228, 300, 357 nm
SMILES
[H]N1C2=C([N+]([O-])=O)C=CC=C2C=N1
InChi Code
InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
InChi Key
PQCAUHUKTBHUSA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $36

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    100 mg

    $68

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    250 mg

    $103

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    500 mg

    $135

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    Product Description

    7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS.1 The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moore, P.K., Babbedge, R.C., Wallace, P., et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol. 108, 296-297 (1993).

    2. Bland-Ward, P.A., Pitcher, A., Wallace, P., et al. Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br. J. Pharmacol. 112, 351P (1994).