A potent inhibitor of nNOS
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3-bromo-7-Nitroindazole

Item No. 81345

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-bromo-7-nitro-1H-indazole
CAS Number
74209-34-0
Molecular Formula
C7H4BrN3O2
Formula Weight
242.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >26.5 mg/mlDMSO: >16.6 mg/mlDMSO:Water (10:90): >150 ug/mlDMSO:Water (50:50): >1 mg/mlEthanol: >20 mg/mlPBS pH 7.2: <50 µg/ml
λmax
232, 361 nm
SMILES
O[N](=O)c1cccc2c(Br)n[nH]c12
InChi Code
InChI=1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
InChi Key
NFSTZPMYAZRZPC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $36

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    50 mg

    $68

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    100 mg

    $123

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    250 mg

    $253

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    Product Description

    3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bland-Ward, P.A., Pitcher, A., Wallace, P., et al. Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br. J. Pharmacol. 112, 351P (1994).