A selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase
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ODQ

Item No. 81410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
CAS Number
41443-28-1
Molecular Formula
C9H5N3O2
Formula Weight
187.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.1 mg/mlDMSO: 15 mg/mlEthanol: 0.5 mg/ml
λmax
232, 295 nm
SMILES
O=C1ON=C2C=NC3=CC=CC=C3N21
InChi Code
InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChi Key
LZMHWZHOZLVYDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $68

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    50 mg

    $228

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    100 mg

    $414

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    Product Description

    ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase.1,2 The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garthwaite, J., Southam, E., Boulton, C.L., et al. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol. Pharmacol. 48(2), 184-188 (1995).

    2. Schrammel, A., Behrends, S., Schmidt, K., et al. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol. Pharmacol. 50(1), 1-5 (1996).

    Product Citations

    Pankey, E.A., Bhartiya, M., Badejo, A.M., Jr., et al. Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme. Am. J. Physiol. Heart Circ. Physiol. 300(3), H792-H802 (2011).