A potent inhibitor of iNOS
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1,3-PBIT (dihydrobromide)

Item No. 81500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S,S'-1,3-phenylene-bis(1,2-ethanediyl)bis-isothiourea, dihydrobromide
CAS Number
200716-66-1
Molecular Formula
C12H18N4S2 • 2HBr
Formula Weight
444.2
Purity
≥98%
Formulation
A crystalline solid
SMILES
N/C(SCCC1=CC(CCS/C(N)=N/[H])=CC=C1)=N/[H].Br.Br
InChi Code
InChI=1S/C12H18N4S2.2BrH/c13-11(14)17-6-4-9-2-1-3-10(8-9)5-7-18-12(15)16;;/h1-3,8H,4-7H2,(H3,13,14)(H3,15,16);2*1H
InChi Key
WCXGFTJSDASEPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $21

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    25 mg

    $46

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    50 mg

    $86

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    100 mg

    $152

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    Product Description

    1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 µM, respectively, for the purified human enzymes.1 Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. The Journal of Biological Chemisty 269(43), 26669-26676 (1994).