A potent inhibitor of iNOS and nNOS
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1,4-PBIT (dihydrobromide)

Item No. 81510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea, dihydrobromide
CAS Number
157254-60-9
Molecular Formula
C12H18N4S2 • 2HBr
Formula Weight
444.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
N/C(SCCC1=CC=C(CCS/C(N)=N/[H])C=C1)=N/[H].Br.Br
InChi Code
InChI=1S/C12H18N4S2.2BrH/c13-11(14)17-7-5-9-1-2-10(4-3-9)6-8-18-12(15)16;;/h1-4H,5-8H2,(H3,13,14)(H3,15,16);2*1H
InChi Key
YRRYHMLYGVNPBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $19

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    50 mg

    $74

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    100 mg

    $130

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    500 mg

    $561

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    Product Description

    1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS.1 Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. The Journal of Biological Chemisty 269(43), 26669-26676 (1994).