A potent, selective iNOS inhibitor
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1400W (hydrochloride)

Item No. 81520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride
CAS Number
214358-33-5
Molecular Formula
C10H15N3 • 2HCl
Formula Weight
250.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
C/C(N([H])CC1=CC(CN)=CC=C1)=N\[H].Cl.Cl
InChi Code
InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChi Key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $60

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    10 mg

    $108

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    50 mg

    $451

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    100 mg

    $618

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    Cayman Chemical
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    Product Description

    1400W is a potent, selective inhibitor of iNOS.1 Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.1 In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.1 In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garvey, E.P., Oplinger, J.A., Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. The Journal of Biological Chemisty 272(8), 4959-4963 (1997).

    2. Thomsen, L.L., Scott, J.M.J., Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Res. 57(15), 3300-3304 (1997).

    Product Citations

    Grant, M.A., Baron, R.M., Macias, A.A., et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem. J. 418(1), 103-112 (2009).