1400W (hydrochloride)

1400W is a potent, selective inhibitor of iNOS.¹ Using purified human iNOS, nNOS, and eNOS, 1400W exhibits K_i values of 7 nM, 2 µM, and 50 µM, respectively.¹ In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.¹ In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.²

WARNING This product is not for human or veterinary use.

1. Garvey, E.P., Oplinger, J.A., Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. The Journal of Biological Chemisty 272(8), 4959-4963 (1997).

2. Thomsen, L.L., Scott, J.M.J., Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Res. 57(15), 3300-3304 (1997).

Grant, M.A., Baron, R.M., Macias, A.A., et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem. J. 418(1), 103-112 (2009).