An iNOS inhibitor
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Aminoguanidine (hydrochloride)

Item No. 81530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hydrazinecarboximidamide, monohydrochloride
CAS Number
1937-19-5
Synonyms
  • Aminoguanidinium chloride
  • GER 11
  • Pimagedine
Molecular Formula
CH6N4 • HCl
Formula Weight
110.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >5 mg/mlDMSO: >5.5 mg/mlEthanol: >1.6 mg/mlPBS pH 7.2: >100 mg/ml
SMILES
N/C(NN)=N\[H].Cl
InChi Code
InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChi Key
UBDZFAGVPPMTIT-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

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    100 g

    $154

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    Cayman Chemical
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    Product Description

    Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.1,2 The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.2 Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Joly, G.A., Ayres, M., Chelly, F., et al. Effects of NG-methyl-L-arginine, NG-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem. Biophys. Res. Commun. 199(1), 147-154 (1994).

    2. Misko, T.P., Moore, W.M., Kasten, T.P., et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233(1), 119-125 (1993).

    3. Ruetten, H., and Thiemermann, C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem. Biophys. Res. Commun. 225(2), 525-530 (1996).