YC-1

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC₅₀ values of 11.7-14.6 and 57.3-59.3 µM, respectively.^1,2 In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED₅₀ value of 20 µM.³ At a concentration of 200 µM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively.

WARNING This product is not for human or veterinary use.

1. Wu, C.C., Ko, F.N., Kuo, S.C., et al. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br. J. Pharmacol. 116(3), 1973-1978 (1995).

2. Ko, F.N., Wu, C.C., Kuo, S.C., et al. YC-1, a novel activator of platelet guanylate cyclase. Blood 84(12), 4226-4233 (1994).

3. Friebe, A., Schultz, G., and Koesling, D. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J. 15(24), 6863-6868 (1996).

Genetos, D.C., Cheung, W.K., Decaris, M.L., et al. Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF. J. Mol. Neurosci. 40(3), 360-366 (2010).