An oxidant formed by the reaction of NO with superoxide
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Peroxynitrite

Item No. 81565

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
peroxynitrous acid, sodium salt
CAS Number
14042-01-4
Synonyms
  • Sodium Peroxynitrite
Molecular Formula
ONO2 • Na
Formula Weight
85.0
Formulation (Request formulation change)
A solution in 0.3 M sodium hydroxide
λmax
302 nm
SMILES
O=NO[O-].[Na+]
InChi Code
InChI=1S/HNO3.Na/c2-1-4-3;/h3H;/q;+1/p-1
InChi Key
WLBPQQFLRJVMBK-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 ml

    $72

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    Product Description

    Peroxynitrite is formed in vivo by the reaction of NO with superoxide.1,2,3 It is a powerful oxidizing agent that can initiate lipid peroxidation, oxidize sulfhydryls, and nitrate the aromatic residues of proteins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pryor, W.A., and Squadrito, G.L. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268, L699-L722 (1995).

    2. Beckman, J.S., and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am. J. Physiol. 271(5 Pt 1), C1424-C1437 (1996).

    3. Koppenol, W.H., Moreno, J.J., Pryor, W.A., et al. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem. Res. Toxicol. 5, 834-842 (1992).

    Product Citations

    Tarabová, B., Lukeš, P., Hammer, M.U., et al. Fluorescence measurements of peroxynitrite/peroxynitrous acid in cold air plasma treated aqueous solutions. Phys. Chem. Chem. Phys. 21(17), 8883-8896 (2019).

    Jung, H.A., Ali, M.Y., Bhakta, K., et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch. Pharm. Res. 40(1), 37-48 (2017).

    Donohue, E., Balgi, A.D., Komatsu, M., et al. Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated proteins by the autophagy inhibitor verteporfin. PLoS One 9(12), 1-30 (2014).

    Jung, H.A., Min, B.S., Yokozawa, T., et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol. Pharm. Bull. 32(8), 1433-1438 (2009).