A specific inhibitor of soluble guanylyl cyclase
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NS 2028

Item No. 81600

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-4H-2,5-dioxa-3,9b-diaza-cyclopenta[a]naphthalen-1-one
CAS Number
204326-43-2
Molecular Formula
C9H5BrN2O3
Formula Weight
269.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >80 mg/mlDMF:PBS (10:90): 5 µg/mlDMSO: >45 mg/mlEthanol: >2 mg/ml
λmax
218, 287 nm
SMILES
Brc1ccc2OCc3noc(=O)n3c2c1
InChi Code
InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
InChi Key
MUDRLQRJCGJJTB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

    $227

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    10 mg

    $396

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    25 mg

    $867

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    Product Description

    NS 2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively.1 S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS 2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay.1 NS 2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olesen, S.P., Drejer, J., Axelsson, O., et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br. J. Pharmacol. 123(2), 299-309 (1998).