A nitric oxide donor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DEA NONOate

Item No. 82100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate
CAS Number
372965-00-9
Synonyms
  • Diethylamine NONOate
  • DEA/NO
Molecular Formula
C4H11N3O2 • C4H11N
Formula Weight
206.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
250 nm
SMILES
CCN(N([O-])N=O)CC.CC[NH2+]CC
InChi Code
InChI=1S/C4H10N3O2.C4H11N/c1-3-6(4-2)7(9)5-8;1-3-5-4-2/h3-4H2,1-2H3;5H,3-4H2,1-2H3/q-1;/p+1
InChi Key
YMXHDQWHPBQRQP-UHFFFAOYSA-O
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $39

    Add

    50 mg

    $106

    Add

    100 mg

    $193

    Add

    500 mg

    $675

    Add
    Product Description

    DEA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2 minutes and 16 minutes at 37°C and 22-25°C, pH 7.4, respectively, to liberate 1.5 moles of NO per mole of parent compound.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ∙NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J. Med. Chem. 34(11), 3242-3247 (1991).

    2. Keefer, L.K., Nims, R.W., Davies, K.M., et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol. 268, 281-293 (1996).

    Product Citations

    Chen, J., Byun, H., She, Q., et al. S-Nitrosylation of the virulence regulator AphB promotes Vibrio cholerae pathogenesis. PLoS Pathog. 18(6), e1010581 (2022).

    Donohue, E., Balgi, A.D., Komatsu, M., et al. Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated proteins by the autophagy inhibitor verteporfin. PLoS One 9(12), 1-30 (2014).