A nitric oxide donor
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DETA NONOate

Item No. 82120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate
CAS Number
146724-94-9
Synonyms
  • Diethylenetriamine NONOate
  • NOC-18
Molecular Formula
C4H13N5O2
Formula Weight
163.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
aqueous buffers: >100 mg/ml
λmax
252 nm
SMILES
[NH3+]CCN(N(N=O)[O-])CCN
InChi Code
InChI=1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
InChi Key
PAOXTYJXTPPVHU-UHFFFAOYSA-O
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $43

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    50 mg

    $151

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    100 mg

    $280

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    500 mg

    $1,073

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    Product Description

    DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hrabie, J.A., Klose, J.R., Wink, D.A., et al. New nitric oxide-releasing zwitterions derived from polyamines. The Journal of Organic Chemistry 58(6), 1472-1476 (1993).

    2. Keefer, L.K., Nims, R.W., Davies, K.M., et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol. 268, 281-293 (1996).

    Product Citations

    Do, T.H., Ma, F., Andrade, P.R., et al. TREM2 macrophages induced by human lipids drive inflammation in acne lesions. Sci. Immunol. 7, eabo2787 (2022).

    Chen, J., Byun, H., She, Q., et al. S-Nitrosylation of the virulence regulator AphB promotes Vibrio cholerae pathogenesis. PLoS Pathog. 18(6), e1010581 (2022).

    Kuhn, M.J., and Sordillo, L.M. Vitamin E analogs limit in vitro oxidant damage to bovine mammary endothelial cells. J. Dairy Sci. 104(6), 7154-7167 (2021).

    Li, L., Zhu, L., Hao, B., et al. iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer. Oncotarget 8(20), 33047-33063 (2017).

    Jarazo Dietrich, S., Fass, M.I., Jacobo, P.V., et al. Inhibition of NOS-NO system prevents autoimmune orchitis development in rats: Relevance of NO released by testicular macrophages in germ cell apoptosis and testosterone secretion. PLoS One 10(6), e0128709 (2015).