A nitric oxide donor
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Spermine NONOate

Item No. 82150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-1-[N-[3-aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino]diazen-1-ium-1,2-diolate
CAS Number
136587-13-8
Molecular Formula
C10H26N6O2
Formula Weight
262.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
aqueous buffers: 100 mg/ml
λmax
252 nm
SMILES
NCCCN(CCCCN(CCCN)[H])N(O)N=O
InChi Code
InChI=1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,18H,1-12H2
InChi Key
QPIOUFBAROSIAN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $53

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    25 mg

    $126

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    50 mg

    $225

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    100 mg

    $344

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    Product Description

    Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ∙NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J. Med. Chem. 34(11), 3242-3247 (1991).

    2. Keefer, L.K., Nims, R.W., Davies, K.M., et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol. 268, 281-293 (1996).

    Product Citations

    Schildknecht, S., Weber, A., Gerding, H.R., et al. The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite. Curr. Med. Chem. 21(3), 365-376 (2014).