A classical nitroxyl (NO-) donor
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Angeli’s Salt

Item No. 82230

Technical Information
Formal Name
disodium diazen-1-ium-1,2,2-triolate
CAS Number
13826-64-7
Synonyms
  • Sodium α-oxyhyponitrite
Molecular Formula
Na2(ONNO2)
Formula Weight
Purity
≥99%
A crystalline solid
H20: 50 mg/mlPBS (pH 7.2): 50 mg/ml
SMILES
[O-]N=N([O-])=O.[Na+].[Na+]
InChi Code
InChI=1S/HN2O3.2Na/c3-1-2(4)5;;/h(H-,1,3,4,5);;/q-1;2*+1/p-1
InChi Key
JMMCYSCEKRWYEJ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Angeli’s salt is regarded as a classical nitroxyl (NO-) donor, but under certain conditions evolution of NO is also observed.1 It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4) to liberate 0.54 moles of NO per mole of parent compound.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maragos, C.M., Morley, D., Wink, D.A., et alComplexes of ∙NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J. Med. Chem. 34(11), 3242-3247 (1991).

    2. Keefer, L.K., Nims, R.W., Davies, K.M., et al"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol. 268, 281-293 (1996).