An S-nitrosothiol NO donor
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Product Categories

Product Type

Biochemicals
Nitric Oxide Donors

Research Area

S-Nitroso-L-glutathione

Item No. 82240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-S-nitroso-L-cysteinyl-glycine
CAS Number
57564-91-7
Synonyms
  • GSNO
Molecular Formula
C10H16N4O7S
Formula Weight
336.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: 1 mg/ml
SMILES
N[C@@H](CCC(N([H])[C@@H](CSN=O)C(N([H])CC(O)=O)=O)=O)C(O)=O
InChi Code
InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5?,6-/m0/s1
InChi Key
HYHSBSXUHZOYLX-GDVGLLTNSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $39

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    10 mg

    $66

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    50 mg

    $193

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    100 mg

    $270

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    Product Description

    S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br. J. Pharmacol. 107(3), 745-749 (1992).

    2. Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal. Biochem. 249(1), 1-9 (1997).

    3. Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51(10), 617-635 (1996).

    4. Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal. Biochem. 238(2), 150-158 (1996).

    Product Citations

    Zhou, Y., Mazur, F., Liang, K., et al. Sensitivity and selectivity analysis of fluorescent probes for hydrogen sulfide detection. Chem. Asian J. 17(5), e202101399 (2022).